Thursday, January 27, 2011
Wednesday, January 26, 2011
San Antonio Breast Cancer Update 2010 - Video Highlights
From OncologyEducation.ca (requires registration - Free)
http://www.oncologyeducation.ca/node/1639
4 Parts:
Part 1 - Hormone Receptor Positive
Part 2 - Adjuvant Bisphosphonates
Part 3 - Adjuvant Chemotherapy
Part 4 - Targeted Therapy
(Dr. Sunil Verma)
Tuesday, January 25, 2011
Thursday, January 20, 2011
Anders Ynnerman: Visualizing the medical data explosion | Video on TED.com
Anders Ynnerman: Visualizing the medical data explosion | Video on TED.com
(TED = Ideas worth sharing)
Rank Ligand - Key mediator in bone destruction
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| Rank Ligand |
The animations help explain in the link noted below.
Osteoblastic versus osteolytic bone metastases
Bone metastases are often characterized by their radiographic appearance as either osteolytic, osteoblastic, or mixed.
Most patients with breast cancer have predominantly mixed or osteolytic lesions. In contrast, patients with prostate cancer are often found to have predominantly osteoblastic lesions. However, regardless of appearance, there is significant osteolytic activity. In fact, osteolytic activity in these lesions often is comparable with, if not higher than, that typically seen in breast cancer and multiple myeloma. Such activity has been demonstrated by markedly elevated biochemical markers of bone resorption in the serum and urine of such patients. Only in multiple myeloma do purely lytic bone lesions develop.
Learn more at:
http://www.rankligand.ca/ Read more...
Tuesday, January 18, 2011
Bleomycin-Induced Flagellate Hyperpigmentation
Most tissues contain a cysteine proteinase capable of hydrolyzing and inactivating bleomycin.
The reduced concentration of bleomycin hydrolase in the skin and lung, as compared with other tissues, may explain the medication's adverse reaction profile.
The patient was counseled that the flagellate hyperpigmentation usually fades over a period of several months after the cessation of the medication.
During the past year, the hyperpigmentation in this patient has faded but not yet resolved.
Read more...
Nilotinib & QT Prolongation
QT interval prolongation may occur, which may in turn result in torsades de pointes, leading to syncope, seizure, and/or death. Sudden deaths have been reported (0.1-1%); ventricular repolarization abnormalities may have contributed.
Prolongation is concentration-dependent. Significant prolongation may occur if taken inappropriately with food, and/or strong CYP3A4 inhibitors, and/or medicines with a known potential to prolong QT interval. The presence of hypokalemia and hypomagnesemia may further enhance this effect.
Drugs that prolong QT interval should be avoided due to the risk of potentially fatal arrhythmias.
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