Potential tamoxifen & methadone interaction
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| Drug Interactions |
Risk Rating D: Consider therapy modification
Summary: CYP2D6 Inhibitors (Moderate) may decrease the metabolism of Tamoxifen. Specifically, CYP2D6 inhibitors may decrease the formation of highly potent active metabolites.
Severity: Major
Reliability Rating: Fair
Patient Management Moderate CYP2D6 inhibitors may reduce the clinical effectiveness of tamoxifen; consider alternative therapy with less of an effect on CYP2D6 activity when possible.
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