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Thursday, April 8, 2010

Oxaliplatin-Induced Peripheral Sensory Neuropathy In Diabetes Patients

Via OncologySTAT:

In conclusion, this pooled analysis indicated that patients with diabetes who are being treated with an oxaliplatin-containing regimen for CRC are not at increased risk of developing PSN. Because of limitations related to the design of the 3 studies, the role of the duration and type of diabetes in the development of PSN during oxaliplatin treatment remains uncertain. Various strategies to prevent oxaliplatin-associated neurotoxicity have been identified but require further study. Larger, prospective trials are needed to confirm the exact nature of any association between diabetes and oxaliplatin-induced neuropathy.

TAKE-HOME MESSAGE:


Patients with diabetes who were treated with FOLFOX4 for colorectal cancer were not at increased risk of developing peripheral sensory neuropathy.

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Pharmacy History

"The earliest known compilation of medicinal substances was ARIANA the Sushruta Samhita, an Indian Ayurvedic treatise attributed to Sushruta in the 6th century BC. However, the earliest text as preserved dates to the 3rd or 4th century AD.
Many Sumerian (late 6th millennium BC - early 2nd millennium BC) cuneiform clay tablets record prescriptions for medicine.[3]

Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC, and the Edwin Smith Papyrus of the 16th century BC.

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the 1st century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui tomb, sealed in 168 BC. Further details on Chinese pharmacy can be found in the Pharmacy in China article."

From Wikipedia: http://en.wikipedia.org/wiki/Pharmacy#History_of_pharmacy

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