In conclusion, this pooled analysis indicated that patients with diabetes who are being treated with an oxaliplatin-containing regimen for CRC are not at increased risk of developing PSN. Because of limitations related to the design of the 3 studies, the role of the duration and type of diabetes in the development of PSN during oxaliplatin treatment remains uncertain. Various strategies to prevent oxaliplatin-associated neurotoxicity have been identified but require further study. Larger, prospective trials are needed to confirm the exact nature of any association between diabetes and oxaliplatin-induced neuropathy.
Patients with diabetes who were treated with FOLFOX4 for colorectal cancer were not at increased risk of developing peripheral sensory neuropathy.