Wednesday, December 21, 2011

Breast cancer gene mutations may have link to heart problems | CTV News

Breast cancer gene mutations may have link to heart problems CTV News

The Canadian Press
Date: Tuesday Dec. 20, 2011 11:35 AM ET

TORONTO — "Two new studies suggest women with gene mutations known to raise the risk of breast and ovarian cancer may also have a greater chance of developing heart disease.

And one of the studies suggests a chemotherapy drug commonly used to treat breast cancer may aggravate the problem in some of these women.

The studies are by researchers at Toronto's St. Michael's Hospital, and are published in the journals Nature Communications and the Journal of Biological Chemistry.

Lead researcher Dr. Subodh Verma says the proteins made by the genes BRCA1 and BRCA2 are critical for repairing damage to cellular DNA.

Women with mutations on the genes don't have enough of the protein, and that may be why they develop breast and ovarian cancer.

Verma's team says their work in mice and in tissue from human hearts suggests the proteins are also crucial for repairing damage to the heart, and women with the mutated genes may be at increased risk of heart disease as a result."

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Pharmacy History

"The earliest known compilation of medicinal substances was ARIANA the Sushruta Samhita, an Indian Ayurvedic treatise attributed to Sushruta in the 6th century BC. However, the earliest text as preserved dates to the 3rd or 4th century AD.
Many Sumerian (late 6th millennium BC - early 2nd millennium BC) cuneiform clay tablets record prescriptions for medicine.[3]

Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC, and the Edwin Smith Papyrus of the 16th century BC.

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the 1st century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui tomb, sealed in 168 BC. Further details on Chinese pharmacy can be found in the Pharmacy in China article."

From Wikipedia:

Journal of Palliative Medicine - Table of Contents

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