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Friday, September 10, 2010

Monoclonal Antibody Nomenclature

So...you've just genetically engineered the latest and greatest MAB and want to give it the creative and unique name it deserves. Well...there are rules about naming such things which must be followed:

• ‘mab’ = monoclonal antibody


• Syllable directly before - humanized, chimeric, etc.

• Prefix = no meaning

• Second syllable = Where the Ab works



Letters - Target - Letters - Origin

Ci (r) - Cardiovascula -a- Rat

Tu (m) - Tumor -o- Mouse

Li (m) - Immune -xi- Chimeric human/mouse

Co (l) - Colon Tumor -zu- Humanized

Me (l) - Melanoma -u- Human

Go (v) - Ovarian Tumour -axo- Rat/murine hybrid

Pr (o) - Prostate


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Posted by cralph at 3:58 PM
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1 comments:

Epigenetics,  December 6, 2010 at 9:30 PM  

Hello friends,

This is very interesting post,epigenetics is the study of inherited changes in phenotype appearance or gene expression caused by mechanisms other than changes in the underlying DNA sequence.Thanks a lot....

Epigenetics

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Pharmacy History

"The earliest known compilation of medicinal substances was ARIANA the Sushruta Samhita, an Indian Ayurvedic treatise attributed to Sushruta in the 6th century BC. However, the earliest text as preserved dates to the 3rd or 4th century AD.
Many Sumerian (late 6th millennium BC - early 2nd millennium BC) cuneiform clay tablets record prescriptions for medicine.[3]

Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC, and the Edwin Smith Papyrus of the 16th century BC.

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the 1st century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui tomb, sealed in 168 BC. Further details on Chinese pharmacy can be found in the Pharmacy in China article."

From Wikipedia: http://en.wikipedia.org/wiki/Pharmacy#History_of_pharmacy

Medscape Pharmacists Headlines

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