Thursday, September 22, 2011

Medical News: Brain Steroids Found Lacking in MS - in Clinical Context, Multiple Sclerosis from MedPage Today

Medical News: Brain Steroids Found Lacking in MS - in Clinical Context, Multiple Sclerosis from MedPage Today


"Individuals with multiple sclerosis (MS) may have impaired production of important neurosteroid molecules in their brains, so replacement therapy could be helpful, researchers said.

Autopsy findings from 16 MS patients showed high expression of micro-RNA molecules in white matter that suppress enzymes responsible for neurosteroid synthesis, particularly allopregnanolone, according to Christopher Power, MD, of the University of Alberta in Edmonton, and colleagues.
The researchers also confirmed that levels of allopregnanolone and other steroids were depressed in the MS patients' white matter, they reported online inBrain.
Similar findings emerged from analyses of mice with experimental autoimmune encephalitis (EAE), a standard model of MS.
Most strikingly, treating the animals with allopregnanolone partly normalized their behavioral deficits and reduced levels of neuroinflammation and injury to nerve fibers, Power and colleagues indicated.
"These studies are the first report of perturbed neurosteroidogenesis in multiple sclerosis and the related model, EAE, which also showed improved outcomes in terms of neurobehavioural deficits, neuropathology and neuromolecular changes with neurosteroid (allopregnanolone) replacement," they wrote.
"The neurosteroid allopregnanolone, or perhaps closely related compounds, might represent unique therapeutic options for people with multiple sclerosis."


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Welcome and thanks for visiting Onco-P.R.N. - The oncology website with a focus on all things oncology pharmacy/pain/palliative care-related. It is intended to be an information resource for those pharmacist and relevant health care professionals involved in whatever fashion with cancer and palliative care. Stay tuned for the latest and greatest links and information with respect to: oncology medications, continuing education, pharmaceutical care initiatives, pain and symptom control, supportive care topics, and whatever else that might fit into the theme.

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Pharmacy History

"The earliest known compilation of medicinal substances was ARIANA the Sushruta Samhita, an Indian Ayurvedic treatise attributed to Sushruta in the 6th century BC. However, the earliest text as preserved dates to the 3rd or 4th century AD.
Many Sumerian (late 6th millennium BC - early 2nd millennium BC) cuneiform clay tablets record prescriptions for medicine.[3]

Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC, and the Edwin Smith Papyrus of the 16th century BC.

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the 1st century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui tomb, sealed in 168 BC. Further details on Chinese pharmacy can be found in the Pharmacy in China article."

From Wikipedia:

Journal of Palliative Medicine - Table of Contents

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