Saturday, September 21, 2013

Lab Notes: Chemo Patients Going to the Dogs

English: Author: Andrew Ryzhkov Rotation of th...
English: Author: Andrew Ryzhkov Rotation of the model of the Paclitaxel molecule generated by the ViewMol3D program. (Photo credit: Wikipedia)
Lab Notes: Chemo Patients Going to the Dogs: "From Dog Food to Chemo?

From Dog Food to Chemo?
"A chemical commonly used as a preservative in dog food prevented the development of peripheral neuropathy associated with treatment with paclitaxel (Taxol) in a mouse model.
The majority of patients given paclitaxel for malignancies such as breast cancer experience painful neuropathy, which can be dose-limiting and can seriously impair quality of life. So a group of researchers from Johns Hopkins led by Ahmet Hoke, MD, PhD, screened some 2,000 compounds for neuroprotective effects in various cell lines.
They identified the antioxidant ethoxyquin -- approved by the FDA for use in animal feed 50 years ago -- as having the most pronounced effects. When they co-administered ethoxyquin with paclitaxel in mice, the intraepidermal nerve fiber damage that predictably occurs in the animals' paws didn't develop.
Hoke's team then were able to identify heat shock protein 90 as the molecule that mediated the neuroprotection through its effects on the levels of two proteins known as ATXN2 and SF3B2.
These findings suggest that ethoxyquin and its derivatives might be suitable for development to help prevent chemotherapy-induced nerve damage in the clinical setting, the researchers suggested in the Annals of Neurology."
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Pharmacy History

"The earliest known compilation of medicinal substances was ARIANA the Sushruta Samhita, an Indian Ayurvedic treatise attributed to Sushruta in the 6th century BC. However, the earliest text as preserved dates to the 3rd or 4th century AD.
Many Sumerian (late 6th millennium BC - early 2nd millennium BC) cuneiform clay tablets record prescriptions for medicine.[3]

Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC, and the Edwin Smith Papyrus of the 16th century BC.

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the 1st century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui tomb, sealed in 168 BC. Further details on Chinese pharmacy can be found in the Pharmacy in China article."

From Wikipedia:

Journal of Palliative Medicine - Table of Contents

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